We got this question a lot - and our answer has been yes for more than three years. 6% of all clusters at CloudAMQP has HiPE enabled - and we are today running thousands of nodes. We have not seen issues with HiPE since 2015.
Erlang VM segfaults was a common issue before, and therefore HiPE was marked as experimental in the RabbitMQ's documentation. Just make sure that you are running a reasonably new Erlang version before you enable HiPE.
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HiPE increases server throughput at the cost of increased startup time. When you enable HiPE, RabbitMQ is compiled at startup. The throughput increases with 20-80%. The drawback of HiPE is that the startup time increases quite a lot too, about 1-3 minutes. It’s therefore not recommended if you require high availability; you want your cluster to come back quickly in the event of failure.
It's possible to enable HiPE, High-performance Erlang, for your dedicated RabbitMQ clusters via the CloudAMQP control panel.
If you have any questions, you can reach out to support@cloudamqp.com.